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Research led by Professor Karen Avraham from Tel-Aviv, with the participation of researchers from the Weizmann Institute and Purdue University published in PNAS USA could cause by removing the micro-RNA in the ears of mice, loss of hearing * future hope Prof. Abraham that could be prevented death of such cells and eliminate wireless doorbell extender a significant portion of the cases of deafness
A new study reveals tiny molecules called microRNAs, essential for the growth and the survival of cells in the inner ear and normal hearing are required. Until now it was known mutations in genes encoding proteins can cause deafness. Now it turns out that the lack of expression of these tiny molecules can lead to hearing loss. This discovery helps to better understand the causes of hearing loss, and may lead to the development of drugs rescue according to a study led by Professor Abraham Fund Department of Molecular Genetics of the person wireless doorbell extender and Biochemistry The Sackler School of Medicine, Tel Aviv University and a post-doctoral student in Dr. Lilach Friedman published yesterday For the first time in the journal Proceedings and funded jointly by the Israeli research fund, the European Union National Institutes of Health and the US.
Conversation wireless doorbell extender Hayadan site explains Prof. Abraham that tiny bits of RNA that before 10 years have not been evaluated properly. Since it appears that they are affecting many sites in plants and animals and therefore it's a system that developed early in evolution. The human body these molecules affect any area of the body: the heart of the brain, nerves, kidneys, liver. They have a very important role in cancer, and even viruses. Professor Abraham Fund specializes in the genetic characteristics of deafness. She says, "When they started to find them all over the body decided that I wanted to look at what's happening in the ear."
Hearing loss is the most common disability in man, but most fault causes are unknown. In most cases, hearing loss is due to poor development wireless doorbell extender or degeneration of inner ear sensory cells, which are called "hair cells". These cells are responsible for electrical stimulation voice translation transmitted to the brain. A group of scientists from Tel Aviv University, along with scientists from the Weizmann wireless doorbell extender Institute and Purdue University, USA, has identified genetic molecules, called microRNAs, essential to the formation of hair cells in the inner ear and the survival of these cells.,
RNA is the chemical carries wireless doorbell extender genetic information from DNA to protein. MicroRNA molecules are tiny pieces of RNA, which determine whether the target protein is created or not. Previous studies have shown, Slmolkolot microRNAs play an important role in embryonic development and various diseases, such as cancer.
In this study used advanced technologies, including DNA chips to identify wireless doorbell extender microRNA molecules ownership role in the inner ear. Researchers led cease production of all micro-RNA molecules hair cells in the inner ear of the mouse. A few weeks later, the hair cells began to degenerate, resulting in the mice lost their hearing. The conclusion from these results is a manufacturing defect microRNA molecules involved wireless doorbell extender apparently deteriorating hearing loss in people born with normal wireless doorbell extender hearing.
Explains Prof. Abraham conversation with a Hayadan: "We took these cells the mice and saw that instead form orderly see top photo, and that allows the operation of the hearing, the hairs are dispersed, lose their shape and enable signal to the brain. Then we decided to isolate the impact of the lack of micro -rn"a ears of zebrafish. Because the ear is similar in all vertebrates can be drawn zebra fish and mouse on the person. wireless doorbell extender
What are your plans for further study? Prof. Abraham: "In the future wireless doorbell extender we want to take the micro-RNA, a synthetic construct them and use them to stop the creation of other proteins. We know plows calls for cell death. When we are born we have about 16 thousand of these cells, and when they begin to die because of genetic damage, exposure to noise, drugs, wireless doorbell extender aging, hearing is lost. If we can find a way to prevent the death of cells we can solve the problem of deafness. In fact our vision is to use micro-RNA therapeutic treatment. "
"MicroRNA molecules involve a promise, wireless doorbell extender that they may serve as a basis for the development of novel drugs. wireless doorbell extender The important role of micro-RNA molecules in animals, regulates the production of many proteins, was discovered only during the last decade. Great efforts are being made to develop methods to introduce these tiny molecules into cells to be used to cure disease. The discovery, Slmolkolot micro- RNA has vital roles in the inner ear, may pave the way to cure hearing loss in the future, "said Professor Abraham.
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